Optical Imaging for Improved Cardiovascular Disease Diagnosis and Management

Friday, February 7, 2014 - 2:00pm
Fung Auditorium | Powell-Focht Bioengineering Hall
Christine P. Hendon, Ph.D.

Assistant Professor, Electrical Engineering

Columbia University

Optical Imaging for Improved Cardiovascular Disease Diagnosis and Management

Abstract: 
There are a large range of diseases and therapies of the heart that can benefit from the information provided by a high-resolution, real time imaging modality. My lab’s goal to develop optical tools for imaging the myocardium, which will provide cardiac electrophysiologist, cardiologist, and heart surgeons a view of the heart wall to aid in disease diagnosis and guide therapy.  In this talk I will discuss the steps we have taken toward clinical translation of optical technologies: optical coherence tomography (OCT) and near infrared spectroscopy (NIRS) for cardiovascular disease diagnosis and management. First, I will describe a project focused on classification of atherosclerotic plaques. I will present a method using depth resolved spectral analysis to identify cholesterol rich plaques within intracoronary OCT pullbacks of patients in vivo. Secondly, I will describe OCT and NIRS catheters developed for monitoring of radiofrequency ablation therapy for the treatment of cardiac arrhythmias in vivo.  Lastly, I will end by describing our steps for procedural guidance by developing characterization algorithms to assess arrhythmogenic substrates.    
Bio: 

Christine P. Hendon joined Columbia University as an Assistant Professor in the Department of Electrical Engineering in 2012 where she is the principal investigator of the Structure Function Imaging Laboratory. Christine received the B.S. degree from Massachusetts Institute of Technology in Electrical Engineering and Computer Science in 2004, along with the M.S. and Ph.D. degrees from Case Western Reserve University in Biomedical Engineering in 2007 and 2010 respectively. She completed her postdoctoral fellowship at the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School in 2012. Christine has been awarded predoctoral fellowships from the NIH and Medtronic and postdoctoral fellowships from the NIH and the Wellman Center. Her work is currently funded by the National Science Foundation, and she has received recognition for her work from Forbes’ 30 under 30 in Science and Healthcare (2012) and MIT Technology Review’s 35 under 35 Innovators (2013).