Biomaterials Nanogeometry for Tissue Engineering and Stem Cell Control

Friday, April 2, 2010 - 2:00pm
Sungho Jin, Ph.D.

Department of Mechanical & Aerospace Engineering
University of California, San Diego

Biomaterials Nanogeometry for Tissue Engineering and Stem Cell Control

Abstract: 
Proper control of nanostructures can produce a very large surface area and topographical features suitable for cell adhesion and growth. Vertically aligned yet laterally spaced TiO2 nanotubes have been utilized to significantly enhance osteoblast cell and bone growth in vitro and in vivo with strong osseointegration. Enhanced activities of cardiomyocytes, endothelial cells and chondrocytes have also been achieved, and guided osteogenic differentiation of stem cells has been demonstrated using substrate nanotopography alone without differentiation-inducing chemical agents. Construction of various biomaterials configurations with nanotubes, nanowires, and networked nanofibers of metallic, ceramic or polymer materials will be described, and the implications of 2-dimensional and 3-dimensional architecturing on cell culture, tissue engineering, neural stimulation, stem cell control and drug delivery will be discussed.